A future manned trip to Mars would subject astronauts to any number of unpredictable hazards--an unprecedentedly complex launch and journey, bombardment by cosmic radiation, and, if sci-fi movies are to be believed, harassment from potentially unfriendly locals. But there's one effect researchers hope to pin down before anybody gets near a launch pad: the physical and psychological effects of the confinement and isolation that such a long trip would engender.
John Matson on Scientific American
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